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First, the pharmacology of nicotine, the primary psychoactive component of tobacco cigarettes, will be discussed including its role in neurotransmission, drug reward pathways, and nicotine dependence [ Pharmacology Cigarette smoke is composed of a complex array of chemical constituents including products such as carboxylic acids, phenols, water, humectants, terpenoids, paraffin waxes, tobacco-specific nitrosamines, (TSNAs), and catechols [ and subunits ( 17, 910

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The primary CV endpoint was the time to major adverse CV event (MACE), defined as CV death, nonfatal myocardial infarction or nonfatal stroke during treatment

PMID 15217537

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To this day, certain brands of chewing tobacco have become iconic among Canadian users, passed down through families and communities as a nod to their roots