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It's worth pointing out that the research comes with a number of caveats

14 Mice exposed to e-cigarette aerosol for 3 months developed carcinogenic DNA changes in the bladder and lungs

So, to prevent depressurization due to a leaky ductwork system, it is imperative to air seal the ductwork and duct termination in order to reduce the amount of negative pressure both in the house and interstitial spaces

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High-level athletes often prefer them because they do not negatively impact lung capacity like combustible tobacco traditionally does

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