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[43] A 2015 study evaluated "a variety of factors that can influence nicotine yield and found that increasing power output from 3 to 7.5 W (an approximately 2.5-fold increase), by increasing the voltage from 3.3 to 5.2 V, led to an approximately 4- to 5-fold increase in nicotine yield." [43] A 2015 study, using a model to approximate indoor air workplace exposure, anticipates greatly reduced exposure to nicotine from e-cigarettes than traditional cigarettes

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Limitations: Burning herbs still produces tar and carbon monoxide

These carcinogens form DNA adducts, leading to mutations in oncogenes and tumor suppressor genes, which initiate malignant transformation