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Potential risks Serious risks and adverse events include: Allergic reaction to the medications or dye used in the injection Shoulder infection Depigmentation of the skin around the injection site (a whitening of the skin) Local fat atrophy around the injection site (thinning of the skin) Rupture of a tendon located in the path of the injection Nerve damage near the shoulder joint Bleeding at the injection site In addition to the above, corticosteroid injections increase the risk of: High blood pressure High blood sugar Decreased immune function Decrease in bone mineral density Bone infection (osteonecrosis) Reproductive hormone imbalance Metabolic changes (eg, increased appetite, weight gain, and fluid retention) These risks are typically associated with higher doses of corticosteroids, multiple injections, and for people with underlying medical conditions such as diabetes and heart problems

Liraglutide, which Novo sells as Victoza for diabetes and Saxenda for weight loss, has been shown in clinical trials to help patients lose about 5 to 7 per cent of their body weight, compared to about 15 per cent for Ozempic or Wegovy

The primary endpoint was percent change in body weight from baseline to week 48

As stated in the introduction, carnitine homeostasis is also gender-specific, being crucial for sperm maturation (Figures 1, 2)