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Robert Norris, the most famous Marlboro Man, didnt smoke, but he did adopt an elephant, pleasingly

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Smoking can cause the blockages and narrowing in your arteries which causes less blood and oxygen flow to your heart, as smoking affects your arteries, So, it can trigger stroke

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The authors located several dozen studies made of the effects of these substances on animals and tissues (preclinical studies) and also on humans (clinical studies)