Treatment with 3 mg liraglutide for 20 weeks reduced appetite and energy intake, resulting in a significant weight loss (7.2 kg) in a large, RCT in people with obesity [15]
Patients who are taking retinoid-derived medications may be building up a toxic amount of vitamin A in their bodies without knowing it
Fig 2: Evolving Competitive Landscape in GLP-1 Based Obesity Medications Abbreviations: AHI: Apnea Hyperpnea Index, CKD: Chronic Kidney Disease, MONW: Metabolic Obesity Normal Weight, OOP: Out-of-pocket, OSA: Obstructive Sleep Apnea, WRC: Weight- related comorbidity
Autophagy 19 (7), 20622077
Importantly, the group that took the placebo was observed to have a significant increase in MDA levels in RBCs ( Figure 4E )
Interestingly, treatment of patients with creatine supplementation and arginine restriction in the case of GAMT patients does seem to improve certain aspects of their phenotype, although not all concerns are eliminated