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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

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A more rigorous discussions and active involvement of medical professionals would be essential and the translatability of findings across preclinical and clinical research should be also considered

[DOI] [PubMed] [Google Scholar] Purves-Tyson TD, Owens SJ, Rothmond DA, Halliday GM, Double KL, Stevens J, McCrossin T, Shannon Weickert C (2017) Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain

Another clinical trial involving people with type 2 diabetes has demonstrated the positive action of IGF-1LR3 on blood sugar control