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In the same study, the phosphorylation of endothelial isoform of nitric oxide synthase (eNOS) in vascular endothelial cells is found to be quickly induced by BPC 157 within 30 min

This activation stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and most significantly for weight management, reduces appetite through effects on hypothalamic appetite centers

Frontiers in Endocrinology, 14, 1120533

10.1038/nature12209 Nature 95 LanannaB