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She was 60 pounds overweight and had tried everything to lose weight and get healthy

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2018;28(8):919924

We assessed the quality of individual studies by the Cochrane risk-of-bias algorithm

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Specific metabolic changes observed during GLP-1 treatment include: Improved insulin sensitivity , allowing cells to use glucose more efficiently Reduced hepatic glucose production , contributing to better glycaemic control Changes in body composition , with loss of both fat mass and some lean tissue Alterations in lipid metabolism , often resulting in improved cholesterol profiles Body composition studies suggest that lean tissue loss typically accounts for approximately 20-30% of total weight lost during GLP-1 therapy, though this varies considerably between individuals and depends on concurrent physical activity and protein intake