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They concluded that Nicotine acts as a gateway drug and exerts a priming effect on cocaine by means of HDAC inhibition . Evidence from a 2011 animal study appearing in the Journal of Science Translational Medicine showed that exposing mice to nicotine during their early developmental stages made them more responsive to cocaine later on

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Genet 48 , 12791283 (2016)

Future research should also further examine the association between early smoking initiation and death from other causes, such as respiratory diseases and cancers, and in other populations