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Frequency of Use: Smokers who use nicotine a lot may develop tolerance

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Collectively, these studies provide evidence that prenatal exposure to nicotine in tobacco smoke can alter brain processes involved in neural development, age-related neurodegenerative conditions like Alzheimers disease, and addiction

Group differences were assessed using ANOVA/Kruskal-Wallis tests for continuous variables and chi-squared tests for categorical variables

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