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Children born to nonsmokers have better health outcomes and fewer developmental issues

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The results consistently indicated that smokers achieved a lower plasma concentration of the drug compared to non-smokers at the same dose, or a lower concentration/dose (C/D) ratio in smokers [28, 43, 61, 70]

The stronger effects when excluding health expenditure suggest that improvements in health services may mitigate some alcohol-related cancer harms, supporting the role of broader system-level factors