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Future studies incorporating pharmacokinetic profiling, long-term efficacy assessment, and inclusion of female subjects are warranted to further clarify its mechanisms and clinical applicability

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It was not until the 1970s when the negative aspects of smoking began to appear, yielding the image of the unhealthy lower-class individual, reeking of cigarette smoke and lack of motivation and drive, which was especially prominent in art inspired or commissioned by anti-smoking campaigns