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Varenicline, which was approved six years after the Guideline was published, is not formally classified as a first-line agent although controlled trials suggest it is equal to (Gonzales et al., 2006) or superior to (Jorenby et al., 2006) sustained-release bupropion

What matters more is the full picture of your lifestyle: what you eat, how active you are, how you sleep, and how you manage stress

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