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Recently published expert guidelines for the treatment of nicotine dependence may help guide pharmacological and psychosocial treatment.[53,67] It is important to note that, even among smokers without co-morbid ADHD, relapse rates are very high

8,51,52 Flavoring chemicals have been implicated as having an effect on the respiratory system

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The modern form emerged with the 2003 patent by Hon Lik for a nicotine delivery system that vaporized liquid to deliver nicotine to the user in an aerosol, leading to sales of the first e-cigarette in 2004 in China [46]

4 More than a quarter-million youth who had never smoked a cigarette used e-cigarettes in 2013. Centers for Disease Control and Prevention, August 25, 2014

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