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It is commonly included in lipotropic formulas because it helps in the breakdown and transport of fats

However, serious toxicity and even deaths have been reported [2,6,7]

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Common : Nausea, headache, GI discomfort Rare: Itching around the mouth, upper respiratory tract symptoms Case Reports Acute hepatitis, livery injury/toxicity: Multiple cases Liver failure requiring transplant: In a 52-year-old woman and a 34-year old man, both associated with the use of G

N Engl J Med 2020;383:1436-46.ArticlePubMed 48

Long-chain acyl-CoA cannot pass that membrane directly