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Some countries, such as Canada, limit nicotine to no more than 20 mg/mL (2%)

doi:10.1016/j.socscimed.2017.03.052

The flavours and customization offered by e-cigarettes adds to its appeal in the market and increases its demand

By young and middle adulthood, male smoking is considerably higher in both countries

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This provides an additional indirect mechanism linking smoking to worsening acne beyond the direct skin effects What the research on smoking and acne actually shows A key piece of research establishing the smoking-acne connection is a 2009 study by Capitanio et al., published in the Journal of Investigative Dermatology , which examined acne patterns in a large cohort of adults and found a specific association between smoking and non-inflammatory acne characterised by comedones and congestion rather than the inflamed papules and pustules of classic inflammatory acne