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The same year, Clooney starred in the Jason Reitman directed comedy-drama Up in the Air , which was initially given limited release, and then a wide release on December 25, 2009

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How It's Used: Injected, snorted or inhaled, smoked, or ingested orally (as counterfeit pills) Why It's Dangerous: Fentanyl's extreme potency means the margin between a "high" dose and a fatal dose is razor thin

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MMWR Morb Mortal Wkly Rep, 73 , 917924, Johansen, A., Rasmussen, S., & Madsen, M

Prices can vary widely depending on availability, but they often remain among the highest in the world