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There was no significant change in the rate of decline in e-cigarette sales in the USA compared to the baseline trend during the period of the San Francisco ban and ALA statement about EVALI (p value for level change = 0.455, p value for trend change = 0.069, Table 1)

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Inspiratory augmentation of the lower esophageal sphincter (mmHg) calculation was performed as described elsewhere [12] as this parameter showed consistency and low variability during the HRM study

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