Yes, unopened injectable semaglutide products should be refrigerated, according to Novo Nordisk , manufacturer of Ozempic and Wegovy
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Pfeifer KJ, Selzer A, Whinney CM, Rogers B, Naik AS, Regan D, et al
In clinical settings, semaglutide treatment yields an impressive 15 to 20 percent weight reduction when accompanied by lifestyle changesranking it among the top weight loss medications available
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Other examples of GLP-1 agonists include exenatide, lixisenatide, liraglutide, albiglutide, and dulaglutide