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A null missense variant in CYP2A6 with a minor allele frequency (MAF) of ~2.5% in Europeans 5 and a CYP2A6 gene deletion variant with an MAF of ~20% in East Asians 6 associated with lower average number of cigarettes smoked daily by slowing the nicotine metabolism in the blood

Darker tobacco likewise has a richer and sometimes more potent nicotine content, while the lighter ones may give you a smoother and less intense nicotine buzz

The very first one will say, Jesus

[249] He won the Drama Desk Award for Outstanding Performance for it