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Due to Xareltos high plasma protein binding, the drug is not dialyzable, meaning dialysis cannot be used to remove the medication from the patients blood

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The companies had argued the FDA had been arbitrary and capricious in the changes it made to PMTA requirements while also being unclear about those changes and what minimum requisites would need to be included to successfully be granted a market authorization and be considered a legal product able to be sold in the American market

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Evaluation of modifiable risk factors that are associated with cigarette smoking can help identify targets that are amendable to intervention