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The knowledge of the delivered dose and its time course using reliable dosimetry techniques is critical to interpreting and potentially extrapolating results from in vitro assays, but also to gain in homogeneity and be able to compare different toxicological studies [18]

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Among them, succinate was produced by IL-1, regulated by hypoxia-inducible factor 1-alpha (HIF1), and the process can be blocked by 2-deoxyglucose via inhibiting glycolysis (62)

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PMID: 127 ZinovkinR