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There's a huge variety in the makeup of these cigarettes and how they are used." The study was published Wednesday as a letter in the New England Journal of Medicine

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Cross-Sectional Association of Wave 5 Tobacco Product Use With Health-Related Quality of Life at Wave 5 Reference group: P30D Exclusive Cigarette Use at Wave 5: When compared to P30D exclusive cigarette use, never use was associated with significantly better HRQoL as measured by all PROMIS components (physical health beta=1.20, confidence interval [CI] [0.44, 1.97])

[21] reported that among adults who never smoked at baseline and did not have asthma or COPD, those who used ECs at baseline were significantly more likely to subsequently develop asthma at an earlier age than those who did not use EC

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