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Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol

Group 4 was given a therapeutic dose (15 mg/kg body weight) of haloperidol (HAL) plus 150 mg/kg body weight of black-seed oil (BSO)

A 2026 UK review of standardised EGb 761 , the Laws 2012 healthy-adult meta-analysis showing no effect, the null GEM and GuidAge trials, the modest mild-dementia benefit, dosing and the bleeding risk versus Dihexas unproven HGF/c-Met synaptogenesis and the c-Met concern

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