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The MR approach minimized reverse causality, residual confounding, and misclassification, which potentially exist in observational studies

Resampling data To confirm that reduced GMV in the right vmPFC was indeed induced by early smoking experience rather than a by-product of smaller vmPFC at baseline, we randomly resampled 200 individuals from the Con and FU-S, respectively, with equivalent GMV between the two groups in both left and right vmPFC at baseline interview

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