Incretins are insulinotrophic hormones (increase insulin secretion) after eating- two main types are recognized ( Table 1 ): Table1: Different Types of GLP-1
Importantly, tirzepatide's benefit persists long-term: discontinuation studies show weight regain occurs, but patients who maintain treatment sustain weight loss
Expect to meet requirements: supervised weight loss programs, documentation, and physician referrals are common prerequisites
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This risk is higher during the first few weeks of treatment or when increasing the dose