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Although having continuously decreased from 70.8% in 1992 to 46.7% in 2009 (Additional file 1: Figure S1), the smoking prevalence in Korean men is still among the highest in member countries of the Organisation for Economic Co-operation and Development (OECD) [13, 14]

Dysregulation of the immune system may lead to an abnormal response to airway inflammation, thereby increasing the risk of COPD [53]

The supernatant is collected in beaker for pH determination [24], before performing the pH electrode calibrated using three different pH buffers (4.1, 7.4 and 9.0)

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