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For COPD, metformin inhibits CS-triggered apoptosis by regulating AMP kinase, while astaxanthin suppresses CS-induced oxidative stress and inflammation by modulating Nrf2 and NF-B pathways

(2016) DOI: 10.2215/CJN.05980616 Tobacco and Pregnancy - ( Ekblad et al

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As a result, you may smell a burning smell coming from these components