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Endorsements must not appear directly below or to the left of the postage area, and must not be visible when the mailpiece is configured for reply purposes (see 507.4.2 and Exhibit 507.1.5.1)

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Sustained stress stimuli that impair mitophagy lead to the accumulation of damaged mitochondria and the release of mtDNA, which, due to its bacterial-like CpG islands, is recognized as a damage-associated molecular pattern (DAMP) by the innate immune system, thereby activating inflammation and promoting chronic inflammatory diseases such as fibrosis and tumors (Li et al., 2019)

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