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Besides this, nicotine has been shown to deplete caffeine more rapidly in the body, essentially cutting the caffeines effects in half while nicotine is also being consumed

American journal of physiology Lung cellular and molecular physiology

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Moreover the point estimates for the Other online (-0.25) and telephone (-0.21) coefficients as well as their confidence intervals are similar and substantially different from the in-person CAI estimate (-0.68)