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Comparing smoking with cholesterol coincides with the explanation of Tolchin, who states that smoking is widely perceived as a nonimmediate danger that affects people only decades in the future (Raban, November 2022)

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Fibroblast-like synoviocytes affected by RA exhibit an induction of proinflammatory cytokinessuch as IL-1a, IL-1B, IL-6, and IL-8, at both mRNA and protein levelsdue to exposure to cigarette smoke condensate 33,34

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Europe has a slightly larger gap (46% of men smoke, 26% of women smoke), while most other regions have few women smokers

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