Eur J Cancer Prev 27:2732
K.JnanaA.ReghunathanD.SharanK.ChandraguthiS
Tandon SK, Chatterjee M, Bhargava A, Shukla V, Bihari V
In amphetamine-induced stereotypy models (a pre-clinical model of schizophrenia-like conditions), DSIP normalised brain metabolism and MAO activity disrupted by long-term amphetamine treatment, establishing a role for adrenergic system normalisation as a mechanism of DSIPs neuroprotective activity
This stability profile enhances its suitability for formulation into injections, solutions, or other dosage forms, supporting reliable preparation and administration
The models of schizophrenia evoked by MK-801 or phencyclidine are used for screening antipsychotic drugs, and do not reflect the pathological changes leading to their formation