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Second, systematic misclassification can interact with sociodemographic or clinical correlates of both reporting and outcomes (for example, stigma, socioeconomic status, or later maternal smoking cessation), producing biased or confounded inferences about who is at risk

Regardless of the approach, the overarching goal remains the same: helping patients move away from combustible cigarette smoking, which remains by far the most harmful form of nicotine use

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Ethics declarations Ethics approval and consent to participate This study was approved by the Clinical Research Ethics Committee of the Catholic Medical Center (approval number: XC140IMI0070)