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Concurrently, a plethora of signaling molecules/pathway therapies exerting either direct or indirect influence on the MQC pathway were investigated, including Mdivi-1 (Drp1 inhibitor) (Liu et al., 2023), BGP-15 (OPA1 activator) (Liu et al., 2023), leflunomide (Mfn2 promoter) (Li C

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5 and 8) and individual amplicon sequencing profiling (Fig