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Based on VigiBase, the World Health Organizations (WHO) adverse drug reaction database, intestinal obstructions are reported over 4.5 times more frequently with incretin-based drugs than with other diabetes medications [10]
Systemic sclerosis and Raynauds phenomenon
Prescription drugs such as semaglutide directly activate GLP-1 receptors, while tirzepatide activates both GIP and GLP-1 receptors
While ok in the short term, long term, significant nutrient, protein and calorie intake puts you at higher risk of certain conditions, including bone loss (osteoporosis), a compromised immune system, hair loss, compromised cell health, nutrient deficiencies, weakness & fatigue, hormonal imbalances, cognitive impairment and sleep disturbances
Bottom line: Vitamin C is safe for both topical and internal use, but starting with a moderate supplement dose and a dedicated lip-safe topical product is the best way to avoid irritation
[DOI] [PubMed] [Google Scholar] Lizzi A
