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An article published in the National Library of Medicine candidly states, "More deaths are caused each year by tobacco use than by human immunodeficiency virus (HIV), illegal drug use, alcohol use, motor vehicle injuries, suicides, and all murders combined." The inescapable fact of smoking is that it kills 480,000 people every year, which is one in every five deaths in the United States

We further found that nicotine exposure significantly altered global sperm DNA methylation patterns, and smoking cessation effectively reversed abnormal DNA methylation

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