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Controllers (i.e., bupropion, varenicline, and nicotine patch) help reduce the impulse to smoke, whereas relievers (short-acting NRTs) aid in managing acute cravings

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These inflammatory cells, factors, and mediators interact to form a complex network that stimulates mucous cell metaplasia, mucus secretion, fibroblast growth and extracellular matrix protein (ECM) synthesis, airway constriction and induces AHR and airway remodeling 5-9 .In recent years, studies have found that Th17 is also essential in the pathogenesis of asthma and is closely related to the recruitment of airway neutrophils 10

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