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To advance clinical translation, future investigations must not only decipher these molecular mechanisms in greater detail but also develop optimized protocols for EV isolation, cargo modification, tissue-specific delivery systems, and large-scale manufacturing to maximize therapeutic efficacy

Demand has been particularly strong for ingredients such as fiber, berberine, probiotics, and chromium that are often positioned to support healthy satiety, normal glucose metabolism, and overall metabolic wellness

PubChem CID: 156588324

Diet-induced obese (DIO) C57BL/6 J male mice were purchased from Jackson Laboratory (#380050, Bar Harbor, ME) at 16 weeks of age

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