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Things such as the pipe itself, how often you smoke it, how long you let it rest, what type of tobacco blend you smoke in it, etc

Health effects associated with smoking: a Burden of Proof study

Available at: cdc.gov/tobacco/data_statistics/fact_sheets/smokeless/products_marketing/index.htm

For example, although EGFR mutations are more common in never-smokers, one-third of lung cancers with EGFR mutations occur in smokers therefore, knowledge of driver mutations and corresponding treatments gleaned from studies of never-smokers may benefit smokers with the disease

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