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Smoking and smokeless tobacco (snus, snuff, chew) is the cause of many diseases and conditions, including lung disease, heart disease, respiratory illnesses and several types of cancer

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Single-cell RNA sequencing demonstrated a reduction in the percentage of all somatic cell types, indicating severe damage to interstitial tissue

Furthermore, current smokers have been shown to have a higher HCC risk (HR = 2.46, 95% CI = 1.773.43) in a dose-dependent manner with the number of cigarettes smoked [104]