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Aliment Pharmacol Ther (1999) 13:140311.10.1046/j.1365-2036.1999.00630.x 60 BrantSRPiccoMFAchkarJPBaylessTMKaneSVBrzezinskiAet alDefining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohns disease phenotypes

PubMed and Scopus databases were searched in April 2024 using the search terms: (never-smokers OR never smokers OR never smok* OR nive OR healthy) AND (e-cig* OR e-cigarette OR ENDS OR electronic cigarette*) AND (respir* OR lung) AND (cohort or observational or follow-up OR randomized controlled trial OR RCT)

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Such perforation allows to mix smoke and air, thus reducing the noxious substances concentration

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