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Four g of total RNA from each sample was used for cDNA synthesis

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The stable double--barrel-fold conformation of CTD is important because it provides the necessary structural stability and facilitates the suitable interacting geometry for two binding interfacial regions, i.e., the inter- and intra-monomer NTDCTD contact regions (each formed by one of the two -barrels), ultimately promoting the integrity of the NTDCTD interface

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