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Its hard to diagnose

But the sentence that matters most for dosing is their conclusion that in most experimental situations, indications for bell-shaped dose-response curves of DSIP were found. [5] A bell-shaped (non-monotonic) dose-response means the effect rises to a peak and then declines as dose increases further

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Nausea is the primary side effect and is dose-dependent

I couldn't wrap my head around that and seeing a gastroenterologist at this stage was deemed overly conservative

The second approach, used in several commercial methods, is to assign the target values to assay calibrators traceable to the World Health Organization and the International Federation of Clinical Chemistry and Laboratory Medicine secondary reference materials