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10.1038/s41598-023-47721-5 24

Starting at a low dose and increasing slowly substantially reduces them

Dehkhoda et al

Moreover, curcumin exhibits antiviral activity against several other viruses, including chikungunya virus, Zika virus, dengue virus, hepatitis C virus, coxsackievirus, human papillomavirus, and SARS-CoV-2 (414, 415)

Hassan C, Antonelli G, Dumonceau JM, Regula J, Bretthauer M, Chaussade S et al (2020) Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Update 2020

M1 has a longer half-life about 16 days but contributes a smaller share of the overall pharmacologic effect