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The contraindications for intravenous Vit C supplementation is glucose-6-phosphate dehydrogenase (G6PD) deficiency 13 and chronic renal failure 14

-MSH is a broadly anti-inflammatory neuropeptide that acts on melanocortin receptors to suppress inflammatory mediators, but its melanocortin activity also drives pigmentation and other effects that complicate therapeutic use

The elderly are more likely than younger adults to develop high blood pressure

However, significant uncertainties remain regarding dosing, standardization, and safety in long-term use

The same reason frozen and thawed biologics lose efficacy

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