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Published July 2, 2025 Updated March 19, 2026 Reviewed by Julie Miller, BA in Language Arts, Editorial Lead, Dr

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Drawing upon the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted three systematic reviews to capture all available peer-reviewed literature pertaining to chewing tobacco and five types of head and neck cancers, ischemic heart disease, and stroke

People suffering from nicotine withdrawal may experience depression as their body adjusts to the lack of nicotine