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I selected these factors as the WHO has identified these as major risk factors for adult health (World Health Organization, 2016) and because clinicians and the public often turn to genetic differences to explain disease occurrence

Nicotine acts on specific 42 nicotinic acetylcholine receptors in the mesocorticolimbic system, through neural pathways that are now seen as a common pathway for addictive drugs

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[4] Through cigarette advertising, Sir Stanley Matthews became aware of emerging scientific research linking smoking to cancer