GSH synthesis can be blocked by BSO, an inhibitor of -glutamylcysteine synthetase (Griffith, 1999), the rate limiting enzyme of this pathway, thus reducing cellular GSH levels and inducing oxidative stress
Results: Walk away feeling refreshed, and revitalized
Recordings were obtained using a Multiclamp 700B amplifier (Molecular Devices, Sunnyvale, CA), Analog signals were low-pass Bessel filtered at 2 kHz, digitized at 10 kHz through a Digidata 144 OA interface (Molecular Devices), and stored in a computer using Clampex 10.2 software (Molecular Devices)
It acts as a powerful antioxidant that protects cells from oxidative stress
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
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