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Available clinical data indicate that adding cagrilintide to semaglutide does not substantially increase nausea or vomiting compared with semaglutide alone ( Management of GLP-1 induced nausea and vomiting The cornerstone of preventing nausea and vomiting with GLP-1based therapy is understanding that gastrointestinal adverse effects are primarily dose related rather than drug specific

Participants also were far more likely to lose at least 5%, 10%, 15%, or 20% of their body weight with semaglutide

HarveySBModiniMJoyceSMilligan-SavilleJSTanLMykletunAet al

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This means that they are very bioavailable